Explore conservation biology and diversity in high resolution

Often only a single, fragmented reference genome is available for a species, genus, or even family, limiting discovery potential. Single Molecule, Real-Time (SMRT) Sequencing provides the longest reads with uniform coverage and the highest consensus accuracy, generating high-quality reference genomes and contiguous assemblies. These comprehensive assemblies capture undetected SNPs, fully intact genes, and regulatory regions embedded in complex structures that fragmented draft genomes often miss.

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Make direct, evidence-based genome annotations

A single gene may code for a surprising number of proteins, each with a distinct biological function. This is especially true in higher organisms. The PacBio Isoform Sequencing (Iso-Seq) method employs long reads to sequence transcript isoforms of up to 10 kb in their entirety. Surveying this transcript diversity, either broadly or in a targeted fashion, reveals key information about the frequency and types of alternative transcription, improving genome annotation and gene discovery.

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Publication: Magrini, Vincent et al. (2018) Improving eukaryotic genome annotation using single molecule mRNA sequencing. BMC Genomics